WHAT ARE Exosomes?

  • Being on the cutting edge of longevity medicine means having access to procedures that most physicians don’t offer.

  • Exosomes are a signaling molecule that stem cells use to talk to each other. This causes your body to turn back the aging clock in a variety of ways!

  • Exosomes are responsible for all cellular communication throughout the human body.

  • “Finding better ways to better repair, replace and restore.”

  • Exosomes are defined as small vesicles ranging from 30-100nm in size that are found in nearly all eukaryotic fluids and facilitate a range of important cellular functions. They transfer DNA, RNA, and proteins to other cells, thereby altering the function of the target cells. (via BioInformant)

VIDEO: “What Are Exosomes?” (via BioInformant)

VIDEO: “Exosomes: nanoparticles offering a new future to cure disease | TEDx Talks | Shivani Sharma” (via YouTube)


(Source: organicell.com)

What are Exosomes?

Part 1:

Exosomes have an endosomal origin and are released by many different cell types, participating in different physiological and/or pathological processes. Depending on their origin, they can alter the fate of recipient cells according to the information transferred.

Part 2:

Isolating the beneficial signals given out by stem cells and using them rather than the stem cells themselves are the next generation as a therapy. Other cells will react to these messaging signals and will change their behavior accordingly. There is a tremendous therapeutic potential of extracellular vesicles, particularly exosomes.

Part 3:

THE MESSENGERS

Extracellular vesicles (EV’s) consist of exosomes and microvesicles, which are released directly from the cell membrane. EV’s can mediate cell–cell communication and are involved in many processes, including immune signaling, angiogenesis, stress response, senescence, proliferation, and cell differentiation. EV’s are involved in restoring tissue and organ damage, and may partially explain the paracrine effects observed in stem cell-based therapeutic approaches. The function and content of EV’s may also harbor information that can be used in tissue engineering, in which paracrine signaling is employed to modulate cell recruitment, differentiation, and proliferation.(1)

GROWTH FACTORS & CYTOKINES

Growth factors are proteins that may act locally or systemically to affect the growth of cells in several ways. Various cell activities, including division, are influenced by growth factors. Cytokines are a family of low-molecular-weight proteins that are produced by numerous cell types and are responsible for regulating the immune response, inflammation, tissue remodeling and cellular differentiation. Target cells of growth factors and cytokines are mesenchymal, epithelial and endothelial cells. These molecules frequently have overlapping activities and can act in an autocrine or paracrine fashion. A complex network of growth factors and cytokines guides cellular differentiation and regeneration in all organs and tissues.(2)

PARACRINE SIGNALING

Paracrine signaling is a form of cell-to-cell communication in which a cell produces a signal to induce changes in nearby cells, altering the behavior of those cells.

Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling.(3)

(1) Extracellular Vesicles: Potential Roles in Regenerative Medicine

Olivier G. De Jong, Bas W. M. Van Balkom, Raymond M. Schiffelers, Carlijn V. C. Bouten, Marianne C. Verhaar. Front Immunol. 2014; 5: 608.

(2) Effie Ioannidou, “ Therapeutic Modulation of Growth Factors and Cytokines in Regenerative Medicine”, Current Pharmaceutical Design (2006) 12: 2397.

(3) U.S. National Library of Medicine, G04.085.600, Paracrine Communication, Cellular signaling in which a factor secreted by a cell affects other cells in the local environment.

 

key uses + benefits

EXOSOMES HAVE BEEN SHOWN TO HELP WITH ……….

  1. Joints (Arthritis, Injury)

  2. Skin Regeneration

  3. Anti-Aging (Regenerates damaged tissue)

INFO ON EXOSOMES…………..

  • (incomplete/poss. incorrect): WHAT IF YOU COULD HAVE 3X GROWTH FACTORS, SECRETED FOR 3-4 WEEKS INSTEAD OF 3-4 DAYS — the typical amount of time that adult stem cells will work in the body (when delivered for treatments) before being excreted.

  • (incomplete): Unlike some forms of Stem Cell Therapy (where Adult sources are used), with Exosomes, there is nothing for your body to reject. This has some huge advantages!

  • (incomplete): Among the things that Exosomes excrete:

    • MRNA (MESSENGER RNA)

    • MICRORNA

    • THE ADVANTAGE TO THAT IS MESSENGER RNA TRANSLATES THE PROTEIN

    • THE END RESULTS IS THE MRA GO TO THE CELLS AND TELLS THE CELLS TO SYNTHESIZE MORE COPIES OF THE GROWTH FACTOR

  • (incomplete): Exosomes have an extraordinary ability to transfer proteins, DNA, mRNA, non-coding RNAs. (via BioInformant)

EXOSOME THERAPY…….

  • Exosomes are gaining momentum within the medical research community as a type of cell-free therapeutic. For many cell types, exosomes may provide the needed therapeutic effects without the risks of administering cells to patients. (via BioInformant)


stem cell therapy: faq

WHAT IS STEM CELL THERAPY?

WHAT ARE STEM CELLS? ……… (via Predictive Biotech)

Stem cells are the basic building blocks of human tissue. They have the ability to repair, rebuild and rejuvenate tissues throughout the body. When disease or injury strikes, stem cells respond to specific signals and set out to facilitate the healing process by differentiating into specialized cells. These specialized cells then release healing growth factors in response to the distress cell signal in an injured or pathologic area of the body required for the body’s repair.

HOW ARE EXOSOMES DIFFERENT FROM STEM CELLS? ***

WHERE DO STEM CELLS COME FROM? ………

WHERE DO EXOSOMES COME FROM? ***

HOW LONG UNTIL I SEE RESULTS? ***

DOES MY AGE MATTER? ***

ARE EXOSOMES SAFE? ***

DO EXOSOMES CONTAIN DNA? ***